Effect of acute stressor and serotonin transporter genotype on amygdala first wave transcriptome in mice.

ABSTRACT: The most prominent brain region evaluating the significance of external stimuli immediately after their onset is the amygdala. Stimuli evaluated as being stressful actuate a number of physiological processes as an immediate stress response. Variation in the serotonin transporter gene has been associated with increased anxiety- and depression-like behavior, altered stress reactivity and adaptation, and pathophysiology of stress-related disorders. In this study the instant reactions to an acute stressor were measured in a serotonin transporter knockout mouse model. Mice lacking the serotonin transporter were verified to be more anxious than their wild-type conspecifics. Genome-wide gene expression changes in the amygdala were measured after the mice were subjected to control condition or to

SUBMITTER: Hohoff C 

PROVIDER: S-EPMC3594195 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature