MTHFR C677T polymorphism and risk of congenital heart defects: evidence from 29 case-control and TDT studies.

ABSTRACT:

Background

Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme for folate metabolism in humans; it is encoded by the MTHFR gene. Several studies have assessed the association between MTHFR C677T polymorphism and the risk of congenital heart defects (CHDs), while the results were inconsistent.

Methods and findings

Multiple electronic databases were searched to identify relevant studies published up to July 22, 2012. Data from case-control and TDT studies were integrated in an allelic model using the Catmap and Metafor software. Twenty-nine publications were included in this meta-analysis. The overall meta-analysis showed significant association between MTHFR C677T polymorphism and CHDs risk in children with heterogeneity (P heterogeneity = 0.000) and publicatio

SUBMITTER: Wang W 

PROVIDER: S-EPMC3594197 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature