A high-throughput screen to identify enhancers of ADAR-mediated RNA-editing.

ABSTRACT: Adenosine to inosine deamination of RNA is widespread in metazoa. Inosines are recognized as guanosines and, therefore, this RNA-editing can influence the coding potential, localization and stability of RNAs. Therefore, RNA editing contributes to the diversification of the transcriptome in a flexible manner. The editing reaction is performed by adenosine deaminases that act on RNA (ADARs), which are essential for normal life and development in many organisms. Changes in editing levels are observed during development but also in neurological pathologies like schizophrenia, depression or tumors. Frequently, changes in editing levels are not reflected by changes in ADAR levels suggesting a regulation of enzyme activity. Until now, only a few factors are known that influence the activity of AD

SUBMITTER: Garncarz W 

PROVIDER: S-EPMC3594278 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature