C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex.

ABSTRACT: The CCR4-NOT complex was originally identified and its composition and organization characterized in the yeast Saccharomyces cerevisiae. It was first suggested to participate in transcription regulation, but since then it has become clear that it plays a key role in mRNA decay in all eukaryotes, thereby contributing importantly to gene expression regulation. Hence, the mammalian CCR4-NOT complex was recently shown to participate in miRNA-mediated mRNA repression. A better characterization of the composition and organization of this complex in higher eukaryotes is thus warranted. Purifications of the CCR4-NOT complex, performed by others and us, suggest that the protein of unknown function C2ORF29 is associated with this assembly. We demonstrate here that C2ORF29 is indeed a bona fide subun

SUBMITTER: Mauxion F 

PROVIDER: S-EPMC3594285 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature