Identification of reproducible individualized targets for treatment of depression with TMS based on intrinsic connectivity.

ABSTRACT: Transcranial magnetic stimulation (TMS) to the left dorsolateral prefrontal cortex (DLPFC) is used clinically for the treatment of depression however outcomes vary greatly between patients. We have shown that average clinical efficacy of different left DLPFC TMS sites is related to intrinsic functional connectivity with remote regions including the subgenual cingulate and suggested that functional connectivity with these remote regions might be used to identify optimized left DLPFC targets for TMS. However it remains unclear if and how this connectivity-based targeting approach should be applied at the single-subject level to potentially individualize therapy to specific patients. In this article we show that individual differences in DLPFC connectivity are large, reproducible across sessi

SUBMITTER: Fox MD 

PROVIDER: S-EPMC3594474 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature