Individual differences in neural correlates of fear conditioning as a function of 5-HTTLPR and stressful life events.

ABSTRACT: Fear learning is a crucial process in the pathogeneses of psychiatric disorders, which highlights the need to identify specific factors contributing to interindividual variation. We hypothesized variation in the serotonin transporter gene (5-HTTLPR) and stressful life events (SLEs) to be associated with neural correlates of fear conditioning in a sample of healthy male adults (n = 47). Subjects were exposed to a differential fear conditioning paradigm after being preselected regarding 5-HTTLPR genotype and SLEs. Individual differences in brain activity as measured by functional magnetic resonance imaging (fMRI), skin conductance responses and preference ratings were assessed. We report significant variation in neural correlates of fear conditioning as a function of 5-HTTLPR genotype. Speci

SUBMITTER: Klucken T 

PROVIDER: S-EPMC3594727 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature