Vertebrate paralogous conserved noncoding sequences may be related to gene expressions in brain.

ABSTRACT: Vertebrate genomes include gene regulatory elements in protein-noncoding regions. A part of gene regulatory elements are expected to be conserved according to their functional importance, so that evolutionarily conserved noncoding sequences (CNSs) might be good candidates for those elements. In addition, paralogous CNSs, which are highly conserved among both orthologous loci and paralogous loci, have the possibility of controlling overlapping expression patterns of their adjacent paralogous protein-coding genes. The two-round whole-genome duplications (2R WGDs), which most probably occurred in the vertebrate common ancestors, generated large numbers of paralogous protein-coding genes and their regulatory elements. These events could contribute to the emergence of vertebrate features. Howev

SUBMITTER: Matsunami M 

PROVIDER: S-EPMC3595034 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature