β-Adrenergic regulation of cardiac progenitor cell death versus survival and proliferation.

ABSTRACT:

Rationale

Short-term β-adrenergic stimulation promotes contractility in response to stress but is ultimately detrimental in the failing heart because of accrual of cardiomyocyte death. Endogenous cardiac progenitor cell (CPC) activation may partially offset cardiomyocyte losses, but consequences of long-term β-adrenergic drive on CPC survival and proliferation are unknown.

Objective

We sought to determine the relationship between β-adrenergic activity and regulation of CPC function.

Methods and results

Mouse and human CPCs express only β2 adrenergic receptor (β2-AR) in conjunction with stem cell marker c-kit. Activation of β2-AR signaling promotes proliferation associated with increased AKT, extracellular signal-regulated kinase 1/2, and endothelial NO synthase phosph

SUBMITTER: Khan M 

PROVIDER: S-EPMC3595054 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature