Excessive aggression as model of violence: a critical evaluation of current preclinical methods.

ABSTRACT:

Rationale

Preclinical experimental models of pathological aggressive behavior are a sorely understudied and difficult research area.

Objectives

How valid, reliable, productive, and informative are the most frequently used animal models of excessive aggressive behavior?

Methods

The rationale, key methodological features, supporting data, and arguments as well as their disadvantages and limitations of the most frequently used animal models for excessive aggressive behavior are summarized and their validity and reliability are evaluated.

Results

Excessive aggressive behavior is validly and reliably seen in (1) a proportion of feral-derived rats and selectively bred mice; (2) rats with compromised adrenal function resulting in a hypoglucocorticoid state; (3) a sign

SUBMITTER: Miczek KA 

PROVIDER: S-EPMC3595336 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature