Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study.

ABSTRACT:

Purpose

To identify a robust prognostic gene expression signature as an independent predictor of survival of patients with acute myeloid leukemia (AML) and use it to improve established risk classification.

Patients and methods

Four independent sets totaling 499 patients with AML carrying various cytogenetic and molecular abnormalities were used as training sets. Two independent patient sets composed of 825 patients were used as validation sets. Notably, patients from different sets were treated with different protocols, and their gene expression profiles were derived using different microarray platforms. Cox regression and Kaplan-Meier methods were used for survival analyses.

Results

A prognostic signature composed of 24 genes was derived from a meta-analysis of Cox

SUBMITTER: Li Z 

PROVIDER: S-EPMC3595425 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature