Clinicopathologic findings predictive of relapse in children with stage III favorable-histology Wilms tumor.

ABSTRACT:

Purpose

Stage III designation in NWTS-5 (National Wilms Tumor Study-5) was determined by four pathologic criteria: positive lymph nodes (LNs), peritoneal implants, residual disease, and tumor rupture. The objective of this study was to determine the prognostic significance of each of the stage III criteria.

Patients and methods

Children with stage III Wilms tumor (WT) treated in NWTS-5 were assessed for event-free (EFS) and overall survival (OS). Sites of relapse and molecular status of tumors are reported. EFS and OS are reported 8 years after diagnosis.

Results

There were 569 patients with local stage III favorable-histology (FH) WT in this analysis, of whom 109 had overall stage IV disease. LN involvement alone was the most frequent criterion for stage III designat

SUBMITTER: Ehrlich PF 

PROVIDER: S-EPMC3595426 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature