Lack of HLA predominance and HLA shared epitopes in biliary Atresia.

ABSTRACT:

Unlabelled

Biliary atresia (BA) is characterized by progressive inflammation and fibrosis of bile ducts. A theory of pathogenesis entails autoimmune-mediated injury targeting bile duct epithelia. One of the strongest genetic associations with autoimmunity is with HLA genes. In addition, apparently dissimilar HLA alleles may have similar antigen-binding sites, called shared epitopes, that overlap in their capacity to present antigens. In autoimmune disease, the incidence of the disease may be related to the presence of shared epitopes, not simply the HLA allelic association.

Aim

To determine HLA allele frequency (high-resolution genotyping) and shared epitope associations in BA.

Results

Analysis of every allele for HLA-A, -B, -C, -DRB1, -DPB1 and -DQB1 in 180 BA and 36

SUBMITTER: Mack CL 

PROVIDER: S-EPMC3595468 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature