Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors.

ABSTRACT: Despite several therapies being currently available to treat inflammatory diseases, new drugs to treat chronic conditions with less side effects and lower production costs are still needed. An innovative approach to drug discovery, the Connectivity Map (CMap), shows how integrating genome-wide gene expression data of drugs and diseases can accelerate this process. Comparison of genome-wide gene expression data generated with annexin A1 (AnxA1) with the CMap revealed significant alignment with gene profiles elicited by histone deacetylase inhibitors (HDACIs), what made us to hypothesize that AnxA1 might mediate the anti-inflammatory actions of HDACIs. Addition of HDACIs (valproic acid, sodium butyrate and thricostatin A) to mouse macrophages caused externalization of AnxA1 with concomitant

SUBMITTER: Montero-Melendez T 

PROVIDER: S-EPMC3595482 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature