Dynamics of fast and slow inhibition from cerebellar golgi cells allow flexible control of synaptic integration.

ABSTRACT: Throughout the brain, multiple interneuron types influence distinct aspects of synaptic processing. Interneuron diversity can thereby promote differential firing from neurons receiving common excitation. In contrast, Golgi cells are the sole interneurons regulating granule cell spiking evoked by mossy fibers, thereby gating inputs to the cerebellar cortex. Here, we examine how this single interneuron class modifies activity in its targets. We find that GABA(A)-mediated transmission at unitary Golgi cell --> granule cell synapses consists of varying contributions of fast synaptic currents and sustained inhibition. Fast IPSCs depress and slow IPSCs gradually build during high-frequency Golgi cell activity. Consequently, fast and slow inhibition differentially influence granule cell spike tim

SUBMITTER: Crowley JJ 

PROVIDER: S-EPMC3595538 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature