Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients.

ABSTRACT:

Introduction

There are now over 30 confirmed loci predisposing to rheumatoid arthritis (RA). Studies have been largely undertaken in patients with anticyclic citrullinated peptide (anti-CCP) positive RA, and some genetic associations appear stronger in this subgroup than in anti-CCP negative disease, although few studies have had adequate power to address the question. The authors therefore investigated confirmed RA susceptibility loci in a large cohort of anti-CCP negative RA subjects.

Methods

RA patients and controls, with serological and genetic data, were available from UK Caucasian patients (n=4068 anti-CCP positive, 2040 anti-CCP negative RA) and 13,009 healthy controls. HLA-DRB1 genotypes and 36 single nucleotide polymorphisms were tested for association between contr

SUBMITTER: Viatte S 

PROVIDER: S-EPMC3595982 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature