Construction of a computable network model for DNA damage, autophagy, cell death, and senescence.

ABSTRACT: Towards the development of a systems biology-based risk assessment approach for environmental toxicants, including tobacco products in a systems toxicology setting such as the "21st Century Toxicology", we are building a series of computable biological network models specific to non-diseased pulmonary and cardiovascular cells/tissues which capture the molecular events that can be activated following exposure to environmental toxicants. Here we extend on previous work and report on the construction and evaluation of a mechanistic network model focused on DNA damage response and the four main cellular fates induced by stress: autophagy, apoptosis, necroptosis, and senescence. In total, the network consists of 34 sub-models containing 1052 unique nodes and 1538 unique edges which are supporte

SUBMITTER: Gebel S 

PROVIDER: S-EPMC3596057 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature