No association between ovarian cancer susceptibility variants and breast cancer risk among Chinese women.

ABSTRACT:

Background

As breast and ovarian cancers may have similar etiologies, this study aimed to evaluate the hypothesis that breast cancer shares common genetic susceptibility variants with ovarian cancer.

Methods

Ten genetic variants in nine loci were previously identified to be associated with ovarian cancer risk among Caucasian women; an additional 353 variants in high-linkage disequilibrium (r(2) ≥ 0.6) among Han Chinese were identified. Data were available from the Affymetrix Genome-Wide Array (6.0) or MACH imputation for 25 and 78 common genetic variants [minor allele frequency (MAF) ≥0.05], respectively. Associations with breast cancer risk were evaluated by additive logistic regression models among 2,918 breast cancer cases and 2,324 controls.

Results

No association

SUBMITTER: Ma X 

PROVIDER: S-EPMC3596432 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature