Alcohol consumption, folate intake, hepatocellular carcinoma, and liver disease mortality.

ABSTRACT:

Background

Excessive alcohol consumption is a well-established risk factor for liver disease and hepatocellular carcinoma (HCC). Previous studies have found that increased alcohol consumption can lead to lower absorption of folate. Conversely, higher folate intake has been inversely associated with liver damage and HCC. In the current study, we investigate the effect of alcohol consumption and folate intake on HCC incidence and liver disease mortality in the NIH-American Association of Retired Persons Diet and Health Study.

Methods

The study population included 494,743 participants who reported at baseline their dietary intake for the previous year. Alcohol and folate were analyzed with hazards ratios (HR) and 95% confidence intervals (CI) using multivariate Cox proportional

SUBMITTER: Persson EC 

PROVIDER: S-EPMC3596467 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature