A 5'-flanking region polymorphism in toll-like receptor 4 is associated with gastric cancer in a Chinese population.

ABSTRACT:

Objective

Inflammation induced by H.pylori colonization in the stomach is related to the development of gastric cancer and the genetic variations of the genes involved in the immune responses modify the host response to the infection. The aim of this study was to evaluate whether polymorphisms in the toll-like receptor 4 (TLR4) gene, a key regulator of both innate and adaptive immunity, were related to the susceptibility to gastric cancer in a Chinese population.

Methods

Two variations in the 5'-flanking region of TLR4 (rs1927914 T > C and rs10759932 T > C) were genotyped by using the PCR-restriction fragment length polymorphism (RFLP) assay in a case-control study of 1,053 incident gastric cancer cases and 1,100 cancer-free controls in a Chinese population.

Results

I

SUBMITTER: Huang H 

PROVIDER: S-EPMC3596543 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature