Association of transforming growth factor-β1 gene variants with risk of coal workers' pneumoconiosis.

ABSTRACT:

Objective

The aim of this case-control study was to explore whether five tagging single nucleotide polymorphisms (tSNPs) within the transforming growth factor-β1 (TGF-β1) gene were involved in manifestation of inflammatory and fibrotic processes associated with coal workers' pneumoconiosis (CWP).

Methods

The study included 508 CWP patients and 526 controls who were underground coal miners from Xuzhou Mining Business Group. Five tSNPs were selected from the HapMap and detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.

Results

The single SNP analysis showed that the genotype frequencies of SNP2 (rs1800470, +869T/C, extron 1) and SNP5 (rs11466345, intron 5) in CWP cases were significantly different from those in controls. Mu

SUBMITTER: Qian H 

PROVIDER: S-EPMC3596592 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature