Hydrogen water consumption prevents osteopenia in ovariectomized rats.

ABSTRACT:

Background and purpose

Accumulating evidence indicates an important role of oxidative stress in the progression of osteoporosis. Recently, it was demonstrated that hydrogen gas, as a novel antioxidant, could selectively reduce hydroxyl radicals and peroxynitrite anion to exert potent therapeutic antioxidant activity. The aim of the present work was to investigate the effect of hydrogen water (HW) consumption on ovariectomy-induced osteoporosis.

Experimental approach

Ovariectomized rats were fed with HW (1.3 ± 0.2 mg·L⁻¹) for 3 months. Then, blood was collected and femur and vertebrae were removed for evaluation of the effect of HW on bone.

Key results

HW consumption in ovariectomized rats had no significant effect on oestrogen production, but prevented the reduction o

SUBMITTER: Guo JD 

PROVIDER: S-EPMC3596646 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature