Intervisit variability of visual parameters in Leber congenital amaurosis caused by RPE65 mutations.

ABSTRACT:

Purpose

To determine the intervisit variability of kinetic visual fields and visual acuity in patients with Leber congenital amaurosis (LCA) caused by mutations in the RPE65 (Retinal Pigment Epithelium-specific protein 65kDa) gene.

Methods

RPE65-LCA patients (n = 20; ages 11-40 years) were studied on at least two visits separated by fewer than 120 days using Goldmann visual field (GVF) and ETDRS visual acuity (VA) in a retrospective review. GVFs were quantified by computing the spherical coordinates of their vertices and calculating the solid angle subtended, and reported in normalized solid-angle units (nsu) as a percentage of average normal field extent. Repeatability coefficients were calculated using 95% confidence intervals on log(10)-converted variables.

Results

SUBMITTER: Roman AJ 

PROVIDER: S-EPMC3597193 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature