Environmental and genetic factors influence age at menarche in women with polycystic ovary syndrome.

ABSTRACT:

Objective

We hypothesized that body mass index (BMI) and DNA variants would predict age at menarche in polycystic ovarian syndrome (PCOS).

Subjects

Subjects aged 18-45 years with PCOS defined by the National Institutes of Health criteria (n=522) and controls with regular menstrual cycles and no hyperandrogenism (n=472) were studied.

Methods

Age at menarche was compared between PCOS cases and controls and examined as a function of multiple parameters.

Results

There was a strong inverse relationship between BMI and age at menarche in PCOS (r=-0.32, p=5 x lO(-11)). The chromosome 6 rs7759938-T variant was associated with earlier age at menarche in women with PCOS (12.60 +/- 0.09 vs. 13.41 +/- 0.23 years; genotype TT vs. CC; p = 0.006). Age at menarche was predicte

SUBMITTER: Carroll J 

PROVIDER: S-EPMC3597236 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature