Histone deacetylase 2 (HDAC2) regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouse.

ABSTRACT: Changes in histone acetylation occur during oocyte development and maturation, but the role of specific histone deacetylases in these processes is poorly defined. We report here that mice harboring Hdac1(-/+)/Hdac2(-/-) or Hdac2(-/-) oocytes are infertile or sub-fertile, respectively. Depleting maternal HDAC2 results in hyperacetylation of H4K16 as determined by immunocytochemistry--normal deacetylation of other lysine residues of histone H3 or H4 is observed--and defective chromosome condensation and segregation during oocyte maturation occurs in a sub-population of oocytes. The resulting increased incidence of aneuploidy likely accounts for the observed sub-fertility of mice harboring Hdac2(-/-) oocytes. The infertility of mice harboring Hdac1(-/+)/Hdac2(-/-)oocytes is attributed to fail

SUBMITTER: Ma P 

PROVIDER: S-EPMC3597510 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature