Restricted N-glycan conformational space in the PDB and its implication in glycan structure modeling.

ABSTRACT: Understanding glycan structure and dynamics is central to understanding protein-carbohydrate recognition and its role in protein-protein interactions. Given the difficulties in obtaining the glycan's crystal structure in glycoconjugates due to its flexibility and heterogeneity, computational modeling could play an important role in providing glycosylated protein structure models. To address if glycan structures available in the PDB can be used as templates or fragments for glycan modeling, we present a survey of the N-glycan structures of 35 different sequences in the PDB. Our statistical analysis shows that the N-glycan structures found on homologous glycoproteins are significantly conserved compared to the random background, suggesting that N-glycan chains can be confidently modeled with

SUBMITTER: Jo S 

PROVIDER: S-EPMC3597548 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature