Phylogeography of Human T-lymphotropic Virus Type 1 (HTLV-1) Lineages Endemic to Japan.

ABSTRACT: We conducted phylogenetic analyses and an estimation of coalescence times for East Asian strains of HTLV-1. Phylogenetic analyses showed that the following three lineages exist in Japan: "JPN", primarily comprising Japanese isolates; "EAS", comprising Japanese and two Chinese isolates, of which one originated from Chengdu and the other from Fujian; and "GLB1", comprising isolates from various locations worldwide, including a few Japanese isolates. It was estimated that the JPN and EAS lineages originated as independent lineages approximately 3,900 and 6,000 years ago, respectively. Based on archaeological findings, the "Out of Sunda" hypothesis was recently proposed to clarify the source of the Jomon (early neolithic) cultures of Japan. According to this hypothesis, it is suggested that th

SUBMITTER: Otani M 

PROVIDER: S-EPMC3598069 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature