Considering trauma exposure in the context of genetics studies of posttraumatic stress disorder: a systematic review.

ABSTRACT:

Background

Posttraumatic stress disorder (PTSD) is a debilitating anxiety disorder. Surveys of the general population suggest that while 50-85% of Americans will experience a traumatic event in their lifetime, only 2-50% will develop PTSD. Why some individuals develop PTSD following trauma exposure while others remain resilient is a central question in the field of trauma research. For more than half a century, the role of genetic influences on PTSD has been considered as a potential vulnerability factor. However, despite the exponential growth of molecular genetic studies over the past decade, limited progress has been made in identifying true genetic variants for PTSD.

Methods

In an attempt to aid future genome wide association studies (GWAS), this paper presents a systema

SUBMITTER: Digangi J 

PROVIDER: S-EPMC3598333 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature