Interleukin-7 induces recruitment of monocytes/macrophages to endothelium.

ABSTRACT:

Aims

Interleukin-7 (IL-7) is a master regulator of T-cell development and homoeostasis. Increased IL-7 levels are associated with inflammatory diseases. The aims of this study were to determine whether IL-7 is a biomarker for inflammatory conditions or an active participant in atherogenesis.

Methods and results

Advanced atherosclerotic lesions in Apoe(-/-) mice were regressed by long-term cholesterol lowering through treatment with a helper-dependent adenovirus expressing apolipoprotein E (n= 6-10). Using this model, gene expression patterns in the aorta were analysed at an early phase of regression by microarray. After stringent statistical analysis, we found that IL-7 expression is significantly reduced in response to lowering of cholesterol (n= 6). To understand the impor

SUBMITTER: Li R 

PROVIDER: S-EPMC3598429 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature