Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia.

ABSTRACT:

Objective

We aimed to investigate whether cognitive deficits and structural and functional connectivity changes can be detected before symptom onset in a large cohort of carriers of microtubule-associated protein tau and progranulin mutations.

Methods

In this case-control study, 75 healthy individuals (aged 20-70 years) with 50% risk for frontotemporal dementia (FTD) underwent DNA screening, neuropsychological assessment, and structural and functional MRI. We used voxel-based morphometry and tract-based spatial statistics for voxelwise analyses of gray matter volume and diffusion tensor imaging measures. Using resting-state fMRI scans, we assessed whole-brain functional connectivity to frontoinsula, anterior midcingulate cortex (aMCC), and posterior cingulate cortex.

Resu

SUBMITTER: Dopper EG 

PROVIDER: S-EPMC3598452 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature