Diffusion tensor imaging in parkinsonian syndromes: a systematic review and meta-analysis.

ABSTRACT:

Objectives

We performed a systematic review to assess alterations in measures of diffusion tensor imaging (DTI) in parkinsonian syndromes, exploring the potential role of DTI in diagnosis and as a candidate biomarker.

Methods

We searched EMBASE and Medline databases for DTI studies comparing parkinsonian syndromes or related dementias with controls or another defined parkinsonian syndrome. Key details for each study regarding participants, imaging methods, and results were extracted. Estimates were pooled, where appropriate, by random-effects meta-analysis.

Results

Of 333 results, we identified 43 studies suitable for inclusion (958 patients, 764 controls). DTI measures detected alterations in all parkinsonian syndromes, with distribution varying differentially with d

SUBMITTER: Cochrane CJ 

PROVIDER: S-EPMC3598454 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature