The evolutionary rate of antibacterial drug targets.

ABSTRACT:

Background

One of the major issues in the fight against infectious diseases is the notable increase in multiple drug resistance in pathogenic species. For that reason, newly acquired high-throughput data on virulent microbial agents attract the attention of many researchers seeking potential new drug targets. Many approaches have been used to evaluate proteins from infectious pathogens, including, but not limited to, similarity analysis, reverse docking, statistical 3D structure analysis, machine learning, topological properties of interaction networks or a combination of the aforementioned methods. From a biological perspective, most essential proteins (knockout lethal for bacteria) or highly conserved proteins (broad spectrum activity) are potential drug targets. Ribosomal protei

SUBMITTER: Gladki A 

PROVIDER: S-EPMC3598507 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature