Performance of creatinine and cystatin C GFR estimating equations in an HIV-positive population on antiretrovirals.

ABSTRACT:

Objective

To evaluate the performance of Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine, cystatin C, and creatinine-cystatin C estimating equations in HIV-positive patients.

Methods

We evaluated the performance of the Modification of Diet in Renal Disease (MDRD) Study and CKD-EPI creatinine 2009, CKD-EPI cystatin C 2012, and CKD-EPI creatinine-cystatin C 2012 glomerular filtration rate (GFR) estimating equations compared with GFR measured using plasma clearance of iohexol in 200 HIV-positive patients on stable antiretroviral therapy. Creatinine and cystatin C assays were standardized to certified reference materials.

Results

Of the 200 participants, median (IQR) CD4 count was 536 (421) and 61% had an undetectable HIV viral load. Mean (SD) measu

SUBMITTER: Inker LA 

PROVIDER: S-EPMC3598619 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature