Inhaled corticosteroid use is associated with increased circulating T regulatory cells in children with asthma.

ABSTRACT:

Background

T regulatory (Treg) cells are important in balancing immune responses and dysregulation of Treg cells has been implicated in the pathogenesis of multiple disease states including asthma. In this study, our primary aim was to determine Treg cell frequency in the peripheral blood of children with and without asthma. The secondary aim was to explore the association between Treg cell frequency with allergen sensitization, disease severity and medication use.

Methods

Peripheral blood mononuclear cells from healthy control subjects (N = 93) and asthmatic children of varying disease severity (N = 66) were characterized by multi-parameter flow cytometry.

Results

Our findings demonstrate that children with asthma had a significantly increased frequency of Treg cells

SUBMITTER: Singh AM 

PROVIDER: S-EPMC3598778 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature