A survey of protein interaction data and multigenic inherited disorders.

ABSTRACT:

Background

Multigenic diseases are often associated with protein complexes or interactions involved in the same pathway. We wanted to estimate to what extent this is true given a consolidated protein interaction data set. The study stresses data integration and data representation issues.

Results

We constructed 497 multigenic disease groups from OMIM and tested for overlaps with interaction and pathway data. A total of 159 disease groups had significant overlaps with protein interaction data consolidated by iRefIndex. A further 68 disease overlaps were found only in the KEGG pathway database. No single database contained all significant overlaps thus stressing the importance of data integration. We also found that disease groups overlapped with all three interaction data typ

SUBMITTER: Mora A 

PROVIDER: S-EPMC3598893 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature