Molecular immunologic correlates of spontaneous latency in a rabbit model of pulmonary tuberculosis.

ABSTRACT:

Background

Infection of humans with Mycobacterium tuberculosis (Mtb) results in latent tuberculosis infection (LTBI) in 90-95% of immune competent individuals, with no symptoms of active disease. The World Health Organization estimates that 1.5 billion people have LTBI, which can reactivate in the setting of waning host immunity, posing a threat to global TB control. Various animal models have been used to study the pathogenesis of TB. However, besides nonhuman primates, rabbits are the only animal model that fully recapitulates the pathological features of human TB, including progressive disease with necrosis and cavitation or establishment of spontaneous latency.

Results

We defined the molecular immunological correlates of LTBI establishment in a rabbit model of pulmonary

SUBMITTER: Subbian S 

PROVIDER: S-EPMC3598925 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature