CpG oligonucleotides bind TLR9 and RRM-containing proteins in Atlantic salmon (Salmo salar).

ABSTRACT:

Background

Bacterial DNA is well-known for its potent immunostimulatory properties which have been attributed to the abundance of CpG dinucleotides within the genomes of prokaryotes. Research has found that mammalian TLR9 is a receptor which mediates the immune response to CpG DNA; however, its functional properties in non-mammalian vertebrates are still poorly characterized. Leukocytes isolated from lower vertebrates, including teleosts, respond to CpG DNA and TLR9 has been identified in many fish species; however, the ligand-binding properties of fish TLR9 have, so far, not been studied. The fact that some vertebrates, like chicken, lack TLR9 and use an alternative molecule (TLR21) as a receptor for CpGs has questioned the functional conservation of TLR9 within vertebrates.

Re

SUBMITTER: Iliev DB 

PROVIDER: S-EPMC3598971 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature