Genetic variation in APOL1 and MYH9 genes is associated with chronic kidney disease among Nigerians.

ABSTRACT:

Purpose

A region of chromosome 22 which includes APOL1 and MYH9 genes was recently identified as a risk locus for non-diabetic forms of kidney disease, including idiopathic and HIV-associated focal segmental glomerular sclerosis and kidney disease clinically attributed to hypertension among African Americans. The purposes of the current study were, therefore, to examine the frequency of these variants and to determine whether they are associated with chronic kidney disease (CKD) among native Africans.

Methods

To investigate the possible evidence of association between variants in these genes and non-diabetic CKD among West Africans, we performed a case/control analysis in a sample of 166 Nigerians without history of European admixture. Our study included a total of 9 variant

SUBMITTER: Tayo BO 

PROVIDER: S-EPMC3599169 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature