Neural protein gamma-synuclein interacting with androgen receptor promotes human prostate cancer progression.

ABSTRACT:

Background

Gamma-synuclein (SNCG) has previously been demonstrated to be significantly correlated with metastatic malignancies; however, in-depth investigation of SNCG in prostate cancer is still lacking. In the present study, we evaluated the role of SNCG in prostate cancer progression and explored the underlying mechanisms.

Methods

First, alteration of SNCG expression in LNCaP cell line to test the ability of SNCG on cellular properties in vitro and vivo whenever exposing with androgen or not. Subsequently, the Dual-luciferase reporter assays were performed to evaluate whether the role of SNCG in LNCaP is through AR signaling. Last, the association between SNCG and prostate cancer progression was assessed immunohistochemically using a series of human prostate tissues.

R

SUBMITTER: Chen J 

PROVIDER: S-EPMC3599237 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature