Computational prediction of protein-protein complexes.

ABSTRACT:

Background

Protein-protein interactions form the core of several biological processes. With protein-protein interfaces being considered as drug targets, studies on their interactions and molecular mechanisms are gaining ground. As the number of protein complexes in databases is scarce as compared to a spectrum of independent protein molecules, computational approaches are being considered for speedier model derivation and assessment of a plausible complex. In this study, a good approach towards in silico generation of protein-protein heterocomplex and identification of the most probable complex among thousands of complexes thus generated is documented. This approach becomes even more useful in the event of little or no binding site information between the interacting protein molecu

SUBMITTER: Mishra S 

PROVIDER: S-EPMC3599296 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature