Identification of germ cell-specific genes in mammalian meiotic prophase.

ABSTRACT:

Background

Mammalian germ cells undergo meiosis to produce sperm or eggs, haploid cells that are primed to meet and propagate life. Meiosis is initiated by retinoic acid and meiotic prophase is the first and most complex stage of meiosis when homologous chromosomes pair to exchange genetic information. Errors in meiosis can lead to infertility and birth defects. However, despite the importance of this process, germ cell-specific gene expression patterns during meiosis remain undefined due to difficulty in obtaining pure germ cell samples, especially in females, where prophase occurs in the embryonic ovary. Indeed, mixed signals from both germ cells and somatic cells complicate gonadal transcriptome studies.

Results

We developed a machine-learning method for identifying germ

SUBMITTER: Li Y 

PROVIDER: S-EPMC3599307 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature