Polymorphisms in the transcription factor NRF2 and forearm vasodilator responses in humans.

ABSTRACT:

Objective

Oxidative stress is integral to the development of endothelial dysfunction and cardiovascular disease. As NRF2 is a key transcription factor in antioxidant defense, we aimed to determine whether polymorphisms within the promoter region of the gene encoding NRF2 (NFE2L2) would significantly modify vasodilator responses in humans.

Methods

Associations between the -653A/G (rs35652124), -651G/A (rs6706649), and -617C/A (rs6721961) polymorphisms within the NFE2L2 promoter and vascular function were evaluated in healthy African-American (n=64) and white (n=184) individuals. Forearm blood flow (FBF) was measured by strain-gauge venous occlusion plethysmography at baseline and in response to incremental doses of bradykinin or sodium nitroprusside. Forearm vascular resistan

SUBMITTER: Marczak ED 

PROVIDER: S-EPMC3599320 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature