French "real life" experience of clofarabine in children with refractory or relapsed acute lymphoblastic leukaemia.

ABSTRACT:

Background

Clofarabine alone or in combination with cyclophosphamide and etoposide has shown a good efficacy and a tolerable toxicity profile in previous studies of children with relapsed or refractory leukaemia. This report describes a retrospective study of 38 French patients who received clofarabine as a monotherapy or in combination for relapsed or refractory acute lymphoblastic leukaemia (ALL) outside of clinical trials after marketing authorization.

Methods

We retrospectively analysed data for 38 patients, up to 21 years old, attending 17 French centres. Thirty patients received clofarabine alone or in combination for a bone marrow relapse of acute lymphoblastic leukaemia (ALL) or refractory disease and eight patients for a high level of minimal residual disease (MRD).

SUBMITTER: Trioche P 

PROVIDER: S-EPMC3599405 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature