Multi-scale RNA comparison based on RNA triple vector curve representation.

ABSTRACT:

Background

In recent years, the important functional roles of RNAs in biological processes have been repeatedly demonstrated. Computing the similarity between two RNAs contributes to better understanding the functional relationship between them. But due to the long-range correlations of RNA, many efficient methods of detecting protein similarity do not work well. In order to comprehensively understand the RNA's function, the better similarity measure among RNAs should be designed to consider their structure features (base pairs). Current methods for RNA comparison could be generally classified into alignment-based and alignment-free.

Results

In this paper, we propose a novel wavelet-based method based on RNA triple vector curve representation, named multi-scale RNA compariso

SUBMITTER: Li Y 

PROVIDER: S-EPMC3599440 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature