Emergence of novel domains in proteins.

ABSTRACT:

Background

Proteins are composed of a combination of discrete, well-defined, sequence domains, associated with specific functions that have arisen at different times during evolutionary history. The emergence of novel domains is related to protein functional diversification and adaptation. But currently little is known about how novel domains arise and how they subsequently evolve.

Results

To gain insights into the impact of recently emerged domains in protein evolution we have identified all human young protein domains that have emerged in approximately the past 550 million years. We have classified them into vertebrate-specific and mammalian-specific groups, and compared them to older domains. We have found 426 different annotated young domains, totalling 995 domain occurr

SUBMITTER: Toll-Riera M 

PROVIDER: S-EPMC3599535 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature