BioTile, a Perl based tool for the identification of differentially enriched regions in tiling microarray data.

ABSTRACT:

Background

Genome-wide tiling array experiments are increasingly used for the analysis of DNA methylation. Because DNA methylation patterns are tissue and cell type specific, the detection of differentially methylated regions (DMRs) with small effect size is a necessary feature of tiling microarray 'peak' finding algorithms, as cellular heterogeneity within a studied tissue may lead to a dilution of the phenotypically relevant effects. Additionally, the ability to detect short length DMRs is necessary as biologically relevant signal may occur in focused regions throughout the genome.

Results

We present a free open-source Perl application, Binding Intensity Only Tile array analysis or "BioTile", for the identification of differentially enriched regions (DERs) in tiling array

SUBMITTER: Guintivano J 

PROVIDER: S-EPMC3599767 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature