Fine-scale mapping of meiotic recombination in Asians.

ABSTRACT:

Background

Meiotic recombination causes a shuffling of homologous chromosomes as they are passed from parents to children. Finding the genomic locations where these crossovers occur is important for genetic association studies, understanding population genetic variation, and predicting disease-causing structural rearrangements. There have been several reports that recombination hotspot usage differs between human populations. But while fine-scale genetic maps exist for European and African populations, none have been constructed for Asians.

Results

Here we present the first Asian genetic map with resolution high enough to reveal hotspot usage. We constructed this map by applying a hidden Markov model to genotype data for over 500,000 single nucleotide polymorphism markers fr

SUBMITTER: Bleazard T 

PROVIDER: S-EPMC3599818 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature