A diet containing soybean oil heated for three hours increases adipose tissue weight but decreases body weight in C57BL/6 J mice.

ABSTRACT:

Background

Our previous work showed that dietary oxidized linoleic acid given, as a single fatty acid, to LDL receptor knockout mice decreased weight gain as compared to control mice. Other studies have also reported that animals fed oils heated for 24 h or greater showed reduced weight gain. These observations, while important, have limited significance since fried foods in the typical human diet do not contain the extreme levels of oxidized lipids used in these studies. The main goal of this study was to investigate the effects of a diet containing soybean oil heated for 3 h on weight gain and fat pad mass in mice. Additionally, because PPARγ and UCP-1 mediate adipocyte differentiation and thermogenesis, respectively, the effect of this diet on these proteins was also examined.

SUBMITTER: Penumetcha M 

PROVIDER: S-EPMC3599973 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature