A predictive signature gene set for discriminating active from latent tuberculosis in Warao Amerindian children.

ABSTRACT:

Background

Tuberculosis (TB) continues to cause a high toll of disease and death among children worldwide. The diagnosis of childhood TB is challenged by the paucibacillary nature of the disease and the difficulties in obtaining specimens. Whereas scientific and clinical research efforts to develop novel diagnostic tools have focused on TB in adults, childhood TB has been relatively neglected. Blood transcriptional profiling has improved our understanding of disease pathogenesis of adult TB and may offer future leads for diagnosis and treatment. No studies applying gene expression profiling of children with TB have been published so far.

Results

We identified a 116-gene signature set that showed an average prediction error of 11% for TB vs. latent TB infection (LTBI) and for

SUBMITTER: Verhagen LM 

PROVIDER: S-EPMC3600014 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature