Gene rearrangements in hormone receptor negative breast cancers revealed by mate pair sequencing.

ABSTRACT:

Background

Chromosomal rearrangements in the form of deletions, insertions, inversions and translocations are frequently observed in breast cancer genomes, and a subset of these rearrangements may play a crucial role in tumorigenesis. To identify novel somatic chromosomal rearrangements, we determined the genome structures of 15 hormone-receptor negative breast tumors by long-insert mate pair massively parallel sequencing.

Results

We identified and validated 40 somatic structural alterations, including the recurring fusion between genes DDX10 and SKA3 and translocations involving the EPHA5 gene. Other rearrangements were found to affect genes in pathways involved in epigenetic regulation, mitosis and signal transduction, underscoring their potential role in breast tumorigene

SUBMITTER: Jiao X 

PROVIDER: S-EPMC3600027 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature