The expression level of miR-18b in hepatocellular carcinoma is associated with the grade of malignancy and prognosis.

ABSTRACT:

Background

Many studies support the hypothesis that specific microRNA (miRNA) expression in various human cancers including hepatocarcinogenesis is closely associated with diagnosis and prognosis. In hepatocellular carcinoma (HCC), malignancy level is related to the degree of histological differentiation.

Methods

In order to establish a novel biomarker that can determine the degree of malignancy and forecast patient prognosis, we performed a microarray analysis to investigate the miRNA expression profiles in 110 HCC which were comprised of 60 moderately, 30 poorly, and 20 well differentiated HCC.

Results

We found that the expression of 12 miRNAs varied significantly according to the degree of histological differentiation. Particularly, miR-18b expression in poorly dif

SUBMITTER: Murakami Y 

PROVIDER: S-EPMC3600030 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature